We identified eight hub genes (TBC1D2, ATP6V0E1, SPI1, RNASE6, C1QB, C1QC, CSF1R, and C1QA), one hub miRNA (hsa-miR-515-5p), and one lncRNA (XIST), which might be prognostic biomarkers for ESCC. The gene discussed is TBC1D2; the disease is esophageal squamous cell carcinoma.