As shown in Table S3, ESCC samples in TBC1D2 high-expression group were most significantly enriched in translational initiation molecules; ESCC samples in ATP6V0E1, SPI1, RNASE6, C1QB, C1QC, CSF1R, and C1QA high-expression groups were most significantly enriched in adaptive immune response (Tables S4–S10). Here, RNASE6 is linked to esophageal squamous cell carcinoma.