Two mRNA (TBC1D2 and ATP6V0E1) in green module and six mRNAs (SPI1, RNASE6, C1QB, C1QC, CSF1R, and C1QA) in cyan module were considered as real hub mRNAs, and they were closely related to the overall survival in ESCC (Figure 4). This evidence concerns the gene RNASE6 and esophageal squamous cell carcinoma.