AKT1 and cancer: Overexpression of FGFR3 is frequently observed in various cancers, and abnormal expression of FGFR3 could directly or indirectly activate various downstream signaling pathways, such as the FGFR3 signaling pathway (31), the PI3K-AKT signaling pathway (32), and the RAS/RAF/MEK/MAPK pathway (33), which are key mediators of the occurrence and development of malignant tumors.