Current porcine models which are used for cancer research include the APC1311 model of familial adenomatous polyposis producing polyps but no tumor (98), the heterozygous TP53 knockout model of osteosarcoma (99), and a chemically induced porcine HCC (hepatocellular carcinoma) model (100). The gene discussed is TP53; the disease is hepatocellular carcinoma.