Further support for the idea that cDLBCL more closely resembles the ABC form is the observation that virtually all cDLBCL are “double expressers”—a very high proportion of cells in canine DLBCL express both MYC and BCL2 (49), a feature which is associated with significantly poorer outcomes in people, and more frequently seen in ABC DLBCL (although can be present in all forms) (50). This evidence concerns the gene BCL2 and aneurysmal bone cyst.