Firstly, 10 of 13 m6A RNA methylation regulators were identified as playing important roles in the development of ccRCC, including ZC3H13, METTL14 and YTHDF2, FTO, ALKBH5, WTAP, METTL3, YTHDC2, KIAA1429, and RBM15. This evidence concerns the gene FTO and nonpapillary renal cell carcinoma.