Compared to normal tissue samples, ZC3H13, METTL14, and YTHDF2 were down regulated, while FTO, ALKBH5, WTAP, METTL3, YTHDC2, KIAA1429, and RBM15 were up regulated in ccRCC tissue samples (Figure 2D). This evidence concerns the gene YTHDF2 and nonpapillary renal cell carcinoma.