Furthermore, TCGA-portal data revealed that a high level of AVL9 in patients with rectal cancer correlated with poor overall survival, and linc00662 expression level was positively correlated with the expression of AVL9. To validate the role of the linc00662/miR-497-5p/AVL9 axis in CRC, we performed rescue assays. The gene discussed is AVL9; the disease is rectal cancer.