To verify the relationship between linc00662, miR-497-5p, and AVL9 in CRC, we explored the function of miR-497-5p and AVL9. We attempted to dysregulate the expression of miR-497-5p and AVL9 in SW480 cells, as SW480 cells with sh-linc00662-1 showed higher efficiency of regulating the expression of miR-497-5p and AVL9 (Figure 6J and Figure S6). The gene discussed is LINC00662; the disease is colorectal carcinoma.