Both of the HIF-1 (Posadas et al., 2013), ErbB (Liu et al., 2015), PI3K-Akt (Linehan et al., 2010; Sato et al., 2013; Guo et al., 2015), Ras (de Araujo Junior et al., 2015; Chen et al., 2018), Rap1 (Chen et al., 2018), and MAPK signaling pathway (Liu et al., 2015) had been found involved in the pathogenesis of RCC. This evidence concerns the gene EGFR and renal cell carcinoma.