In the present study, PPI analysis shows that RPS6KB1 and CREB1, which are associated with proliferation and differentiation, as well as the proapoptotic protein BAD, may interact with CXCL8. In addition, the levels of RPS6KB1 and CREB1 mRNAs were increased in tissues harvested from patients with the early and advanced stages of CRC, while those of BAD was decreased. This evidence concerns the gene CREB1 and colorectal carcinoma.