Moreno et al. (2018) found upregulation of HSD17B12 is associated ischemic stroke using 82 cases and 67 controls. ALDH2 is generally considered as a gene (Guo et al., 2013) which can protect against ischemic stroke, because overexpression of ALDH2 rescued neuronal survival against 4-HNE treatment in PC12 cells (Lee et al., 2012). This evidence concerns the gene ALDH2 and ischemic stroke.