With a full resolution MHC typing, we identified a hitherto not recognized, novel MHC haplotype (W*01:01:01-DMA*01:01:01-DMB*01:03:01:02-TAP1*01:01:01), which is associated with unsolved CVID in patients with a late onset of symptoms, present a non-progressive form of the disease with an infections only phenotype and post-germinal center defects. The gene discussed is HLA-C; the disease is common variable immunodeficiency.