Kucharzewska et al. demonstrated pro-angiogenic factors in EVs derived from the plasma of patients with GBM and suggested the possibility that GBM EV molecular signature consisting of proangiogenic mediators such as caveolin 1(CAV1), IL8, PDGFs, and MMPs, that could provide a non-invasive, biomarker profile that reflects oxygenation status and aggressiveness of GBM (33). This evidence concerns the gene CXCL8 and glioblastoma.