While the chronicity of WT AAV infection has never been clearly established, a putative evidence of its occurrence is the observation that a significant portion of individuals, aged >60 years old, who harbor anti-AAV1 IgG antibodies also exhibit anti-AAV1 IgM antibodies, an immunoglobulin subtype classically encountered during the course of a running infection (43, 44). The gene discussed is CD40LG; the disease is infection.