Among the enrichment score-driving critical genes of the TCR signaling, the levels of transcripts for ITK and its signaling components (5) such as LCK, GRB2, SLP76, NCK1, FYN, and PLCG are significantly upregulated in caseated granulomas compared to uninvolved lung tissue (Figure 1B). Here, LCP2 is linked to Granuloma.