To test whether this strategy could be used to localize costimulatory domains to tumor cells, K562 cells, which constitutively express B7H6 (23), were incubated with purified human T cells and a sub-optimal dose of anti-CD3 with or without ICOSL-NKp30 vIgD-Fc or control proteins. The gene discussed is NCR3LG1; the disease is neoplasm.