In contrast, other experiments demonstrated that in DSS-treated or pathogen-infected colitis models, commensal A. muciniphila could drive alterations in mucosal constituents, disturb the homeostasis of the mucus layer and further exacerbate inflammation due to excessive degradation of mucin (Ganesh et al., 2013; Seregin et al., 2017). The gene discussed is MUC5AC; the disease is colitis.