Cerebral malaria can lead to the apoptosis of neurons and astrocytes through haemozoin (García Samartino et al., 2010), while Plasmodium falciparum induces the apoptosis of cerebral microvascular endothelial cells via a perforin-dependent process; both these infections result in neurological disorders (Potter et al., 2006). This evidence concerns the gene PRF1 and infection.