APP and early-onset autosomal dominant Alzheimer disease: For Alzheimer’s disease, a disease commonly thought to be a neurotoxic disease and caused by the sequential processing of amyloid-β protein precursor (AβPP), TAZ and YAP activate AβPP-mediated signaling of downstream target genes by forming a triple protein complex with the Mint1/Mint3 and AβPP paralogs APLP1/APLP2 (Orcholski et al., 2011).