Alzahrani et al. (2017) reported that the Scribble interacting protein nitric oxide synthase 1 adaptor protein (NOS1AP) forms a complex with YAP. Importantly, a further study indicates that the Hippo pathway is inhibited in HPV-infected tumors while YAP protein is significantly accumulated in the nucleus of HPV-oropharyngeal squamous cell carcinoma (HPV-OPSCC) cells (Alzahrani et al., 2017). Here, YAP1 is linked to oropharynx squamous cell carcinoma.