Along with an unbiased approach to examine the host miRs regulated by tumor variant LMP1, it will be critical to define how the point mutations at positions 212 and 366 affect the NF-κB, p38, PI3K, and JNK signaling pathways to gain a more thorough picture of how tumor variant LMP1 alters the landscape of host signaling and miR expression. The gene discussed is NFKB1; the disease is neoplasm.