While the B95.8 lab strain of EBV was originally isolated from a patient with infectious mononucleosis, other naturally occurring sequence variants of LMP1 have been isolated and demonstrated to display altered LMP1 function (Sandvej et al., 1997; Dawson et al., 2000; Fielding et al., 2001; Mainou and Raab-Traub, 2006; Vaysberg et al., 2008). This evidence concerns the gene PDLIM7 and infectious mononucleosis.