EGFR and neoplasm: In contrast to observations with GC cells, FPR1 expressed by highly malignant human glioblastoma (GBM) cells (76) by responding to a ligand DAMP annexin (Anx) A1 released by necrotic tumor cells in the microenvironment, trans-activates EGFR and these receptors coordinate to promote GBM cell survival, invasion, and angiogenic factor production (76–80).