Furthermore, scanning electron microscopy (Figure 2A), H&E staining (Figure 2B) and immunofluorescence detection of vWF (Figure 2C) and CD31 (Figure 2D) in the necks of aneurysms showed that sitagliptin significantly promoted endothelialization of the aneurysmal neck, while AMD3100 inhibited endothelialization of the aneurysmal neck (Figures 2E,F). Here, PECAM1 is linked to aneurysm.