FLT4 and obesity due to melanocortin 4 receptor deficiency: Likewise, K14-VEGFR3-Ig mice in which a soluble form of extracellular VEGFR3 (sVEGFR3) that traps VEGF-C and VEGF-D was expressed from keratinocytes, were also resistant to high fat diet induced obesity, hepatic lipid accumulation and metabolic dysfunction (Karaman et al., 2015).