Also, ventricular myocytes exhibit cardiac arrhythmogenic events leading to ventricular arrhythmias which can be prevented in transgenic mice expressing the CaMKII inhibitor AIP targeted to the SR membranes, avoiding phosphorylation of SR proteins (PLN and RyR2) by CaMKII (SR-AIP mice) (Figure 8). Here, RYR2 is linked to Ventricular arrhythmia.