After prolonged ischemia, we showed that preventing PLN phosphorylation exacerbates the functional and structural heart damage after myocardial infarction, suggesting that CaMKII-dependent phosphorylation of PLN observed during reperfusion favors post-ischemic recovery and protects from I/R cardiac damage (Di Carlo et al., 2014). This evidence concerns the gene PLN and myocardial infarction.