Accordingly, TRPV4 expression was remarkably enhanced in breast tumor-derived endothelial cells (B-TECs) and TRPV4 activation with AA or 4αPDD induced migration in B-TECs, but not control human cardiac microvascular endothelial cells (Pla et al., 2012) Conversely, AA-induced BTEC migration was prevented upon cell transfection with a short hairpin RNA selectively targeting TRPV4 (shTRPV4). The gene discussed is TRPV4; the disease is breast neoplasm.