Therefore, considering that O-GlcNAc modulates the function of the cardiovascular and immune systems, which are key in endotoxemic/sepsis-associated conditions and complications, this study tested the hypothesis that acute increases in O-GlcNAc reduce NF-κB activation and expression/release of pro-inflammatory cytokines, improving cardiovascular function in animals with LPS-induced SIRS. This evidence concerns the gene NFKB1 and systemic inflammatory response syndrome.