This study shows that acute protein glycosylation, either by increasing flux in the hexosamine pathway, with glucosamine, or by OGA inhibition, with thiamet-G, improves survival of mice with severe endotoxemia in 40 and 60% (Figure 1), respectively, suggesting that acute increase in O-GlcNAc reduces mortality associated to septic condition. The gene discussed is OGA; the disease is serum lipopolysaccharide activity.