INS and type 2 diabetes mellitus: Most interesting are the responses of MT to the diabetic-like, MI conditions, where in ND-MT there was minimal or no impact on either secretion of the myokines measured or markers of inflammation, which would be consistent with the lack of effects of MI-ND-CM on insulin secretion, while the ability of MI-T2D-CM to suppress GSIS was accompanied by modest changes in p38 and p44/42 MAPK protein expression and phosphorylation.