Meanwhile, as might be expected, the hyperglycemic/hyperinsulinemic/hyperlipidemic T2D-like conditions induced insulin resistance at the level of Akt phosphorylation in ND-MT, but did not exacerbate the already impaired Akt response in T2D-MT; it may be that even more severe (non-physiologic) conditions would be needed to induce even more severe insulin resistance for this response. This evidence concerns the gene AKT1 and type 2 diabetes mellitus.