A similar uncoupling of SkM inflammation and insulin resistance has been seen in obese subjects (Amazou et al., 2016), after SkM-specific over-expression of MCP-1 (Evers-van Gogh et al., 2016), and with palmitate treatment of L6 myotubes (Sinha et al., 2004). Here, CCL2 is linked to Insulin resistance.