In the MetS, CRC, Colitis, and other model experiments, the increase of Fecal butyrate content will reduce the expression of TNF-α, IL-2, NF-κB, and other pro-inflammatory factors (Rodriguez-Cabezas et al., 2002; Hijova et al., 2013; Hald et al., 2016). Here, NFKB1 is linked to colitis.