While a number of studies have investigated the cellular mechanisms underlying modulation of BVR by beta-adrenergic stimulation and the consequent effect on arrhythmia initiation (Johnson et al., 2010, 2013; Szentandrássy et al., 2015), only a few have so far examined mechanisms underlying low frequency oscillation of ventricular APD (Pueyo et al., 2016b; Sampedro-Puente et al., 2019). This evidence concerns the gene BLVRA and cardiac arrhythmia.