PDPN and glioblastoma: However, certain subtypes of glioblastoma are spared form CAT, due to protective effects associated with the expression of specific transforming mutations, such as those of isocitrate dehydrogenase (IDH1), a phenotype that correlates with reduced expression of tissue factor, podoplanin and other genes (Unruh et al., 2016; Tawil et al., 2019) and with normal platelet counts (Unruh et al., 2016).