Synoviocytes isolated from RA patients express P2X1, P2X2, P2X3, P2X4, P2X5, P2X7, P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, P2Y14 receptors whereas in synovial cells from OA patients two membrane ion channels, P2X(1) and P2X(3) receptors, were present (Caporali et al., 2008; Varani et al., 2010). Here, P2RX7 is linked to rheumatoid arthritis.