In cultured vascular endothelial cells, the expressions of miR-455-3p, endothelial nitric oxide synthase (eNOS) protein and NO production are augmented by H2S. Besides, H2S levels and miR-455-3p expressions are also increased in human atherosclerosis plaque, suggesting that the miR-455-3p/eNOS/NO axis is required to H2S to circumvent the development of atherosclerosis (Li et al., 2017). This evidence concerns the gene NOS3 and atherosclerosis.