Recently, H2S induces S-sulfhydration of kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid 2-related factor 2 (Nrf2) dissociation from Keap1, followed by Nrf2 nuclear translocation and anti-oxidize effects in endothelial cells, contributing to the ameliorating effect of H2S on atherosclerosis in the context of diabetes (Xie et al., 2016). Here, NFE2L2 is linked to diabetes mellitus.