Furthermore, in a mouse model of disturbed flow-induced atherosclerosis, application of H2S donor NaHS considerably attenuates the severity of atherosclerosis via upregulating expressions of angiotensin converting enzyme 2 (ACE2), thus converting pro-atherosclerotic Ang II to anti-atherosclerotic angiotensin 1-7 (Ang-(1-7)) (Lin et al., 2017). This evidence concerns the gene ACE2 and atherosclerosis.