Reports have also shown that 10 μmol/L Rg1 can promote the neuron-specific enolase (NSE) expression of rat BMSCs in low-glucose Dulbecco's modified Eagle's medium (DMEM) with or without brain homogenates from rats with dementia; furthermore, this treatment prevented the brain homogenate (dementia rats) induced inhibition of neuronal differentiation and enhanced the differentiation of BMSCs into specific subpopulations of neuron-like cells that express nerve growth factor (NGF) mRNA (Zuo et al., 2007; Wu et al., 2011). The gene discussed is ENO2; the disease is dementia.