GRK2 and cardiovascular disorder: In addition to the above, some targets or signaling pathways are closely related to the treatment of cardiovascular diseases, such as p70S6K, Cyclin D1, phosphatase and tensin homolog deleted on chromosome ten (PTEN), and G Protein-Coupled Receptor Kinase 2 (GRK2) (Glass and Singla, 2011; Lian et al., 2012; Fan et al., 2013; Chen et al., 2017b).