Interleukin-1β (IL-1β) can be modulated by P2X7 receptor (P2X7R) inhibition, induced by its antagonist A-740003, via the P2X7/NLRP3 pathway to attenuate sympathetic nerve sprouting after MI (Yin et al., 2017). The gene discussed is P2RX7; the disease is myocardial infarction.