The activation of cold-inducible the RNA-binding protein (CIRP)/mitogen-activated protein kinase (MAPK) signaling pathway, down-regulation of the janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway, and down-regulation of the angiotensin II (Ang II)/Ang II type 1 receptor (AT1R) pathway can all be induced by a simple compound, H2S, to exert cardio-protective effects like ameliorating myocardial injury, attenuating myocardial fibrosis, or improving myocardial remodeling (Liu et al., 2017; Liu et al., 2018; Zhao et al., 2018). The gene discussed is CIRBP; the disease is Myocardial fibrosis.