In human HFs, we found that high concentrations of DHT (10-5 and 10-6 mol/L) failed to induce the phosphorylation of GSK3β at Ser-9 and thus inhibited β-catenin translocation into the nucleus, while low concentrations of DHT (10-7 mol/L) induced the phosphorylation of GSK3β at Ser-9 and thereby promoted the nuclear translocation of β-catenin (Figure 4). Here, GSK3B is linked to Hand-foot syndrome.