1. Upregulation in patients with early-stage colon cancer2. miRNA AUC = 68.55%; existing marker-CEA AUC = 83.6%;combination miR-125a-3p and carcinoembryonic antigen (CEA) AUC = 85.5%3. miR-125a-3p = significant correlation with only nerve infiltration (P < 0.01), but CEA level correlated with tumor size, infiltration depth, and differentiation degree (P < 0.05, r = 0.3009-0.7270). The gene discussed is CEACAM5; the disease is neoplasm.