Circulating miRNAs are also reported to be better markers than existing markers, for example, (1) cancer antigen-125 (CA-125) measurement and ultrasonography in detecting ovarian cancer (OvCa) (Yokoi et al., 2017) or (2) squamous cell cancer antigen (SCC) and carcinoembryonic antigen (CEA) (Huang et al., 2017). The gene discussed is CEACAM5; the disease is ovarian carcinoma.