Circulating miRNAs are also reported to be better markers than existing markers, for example, (1) cancer antigen-125 (CA-125) measurement and ultrasonography in detecting ovarian cancer (OvCa) (Yokoi et al., 2017) or (2) squamous cell cancer antigen (SCC) and carcinoembryonic antigen (CEA) (Huang et al., 2017). Here, MUC16 is linked to ovarian cancer.