CYP46A1 and Alzheimer disease: Therefore, in the present study, we adopted an in vitro cell model with the CYP46A1 TT or CC genotype, and investigated the role of LincRNA RP11-543C4.3-001 in the effect of CYP46A1 polymorphism in AD-related pathological features, such as 24-OHC and Aβ production, to clarify its role in AD pathology.