In the context of AD, TREM2 regulates the recruitment of microglia to the vicinity of amyloid plaque and limits amyloid or plaque tau seeding (Yuan et al., 2016; Cheng-Hathaway et al., 2018; Leyns et al., 2019; Parhizkar et al., 2019). Here, MAPT is linked to Alzheimer disease.