Specifically, Zheng et al. (2014) found that after exposure to traumatic noise (16 kHz pure tone at 115 dB for 1 h), early (5 mg/kg s.c., 30 min, and every 24 h for five consecutive days post-noise exposure) or late (3 mg/day for 45 week beginning 17.5 week post-noise exposure) treatment with L-baclofen, a GABA-B receptor agonist, failed to prevent development of behavioral evidence of tinnitus in rats. This evidence concerns the gene GABBR1 and Tinnitus.