Equally, region specific responses of astrocytes to neurotrophins (NGF, BDNF) affect wound closure at lesion sites (Cragnolini et al., 2018), while cellular and regional diversity of astrocytes is related to differential transcriptomic changes, during multiple sclerosis and potentially other neurodegenerative diseases (Itoh et al., 2018). This evidence concerns the gene BDNF and multiple sclerosis.