SIRT1 and juvenile Huntington disease: Recently, many studies have suggested that Sirt1 has neuroprotective effects that slow the degeneration common to many neurological diseases, such as AD, Huntington’s disease, and Parkinson’s disease (Jiang et al., 2012; Lalla and Donmez, 2013; Herskovits and Guarente, 2014), and it is important for the regulation of many functions, including metabolism, stress tolerance, cell survival and aging, the inflammatory immune response, endothelial function, and circadian rhythm (Chung et al., 2010).