LRRK2 and Parkinson disease: However, it is remarkable that up to one third of patients with PD are due to LRRK2-gene mutations/PARK8 (Kalia et al., 2015) and almost all patients with Parkin-gene mutations/PARK2 lack LB pathology (Klein and Westenberger, 2012; Poulopoulos et al., 2012).