Park et al. (2017) also found that α-syn is ubiquitinated by NEDD4, an E3 ligase, which interacts with RER1 to induce α-syn degradation by the proteasome system (Chung et al., 2013). Furthermore, in histopathological brain studies from DLB, RER1 has been located in LB-like round structures, presenting colocalization with pS129-α-syn, unlike control brains (Park et al., 2017); indicating the relevance of RER1 in regulating α-syn activity during vesicular trafficking. This evidence concerns the gene RER1 and Lewy body dementia.