LPO, and imbalance in the antioxidative defense markers including the GSH, SOD and nitrite in the brain increases the free radical mediated progression of AD pathogenesis and memory impairments (Sultana et al., 2013[55]; Saharan and Mandal, 2014[46]; Wink et al., 2001[60]; Javed et al., 2012[25]; Susswein et al., 2004[56]). This evidence concerns the gene SOD1 and Alzheimer disease.