PPARA and liver disorder: In contrast, a variety of mouse models and in vitro cell studies have shown that FABP1 regulates fatty acid metabolism associated with peroxisome proliferator-activated receptor alpha (PPARα) in β-oxidation 32, and that it is involved in hepatocellular damage as well as oxidative stress, thus contributing to the progression of liver disease through increased hepatic steatosis and the subsequent activation of hepatic stellate cells 33,34.