ART can reduce the frequency and severityof cryptosporidiosis in PLHIV.68 A correlation study between Cryptosporidium infection withthe CD4+ counts of patients in India showed that the HIV-seropositivepatients with CD4+ <100 cells/mm3 were 6.09 times moresusceptible to be infected by Cryptosporidium (P = .002).49 The findings were consistent with other reports by Sadraei et al69 and Wiwanitkit,44 which reported Cryptosporidium as an opportunistic infectionin HIV-seropositive patients with CD4+ <200/μL. The gene discussed is CD4; the disease is cryptosporidiosis.