One of BRCA2’s key mechanisms inDDR is to recruit RAD51,an evolutionarily conserved recombinase, at the site of DSBs whereit performs DSB repair through HR.20 Additionally,the expression of RAD51 and the rate of RAD51-mediated HR are bothelevated in a wide variety of cancers (e.g., breast, pancreatic).21 Moreover, the cellular amount of RAD51 is positivelycorrelated with resistance to radiotherapies or chemotherapies thatinduce DNA damage.22,23. The gene discussed is RAD51; the disease is cancer.