In line with our hypothesis, 2 increasedthe sensitivity to olaparib in pancreatic cancer cells (BxPC-3) withfully functional BRCA2. Notably, this synergisticeffect was not observed in Capan-1, pancreas adenocarcinoma cellsthat lack BRCA2. 30 Furthermore,to discover more effective compounds, we conducted a chemical modificationcampaign around the triazole moiety. The gene discussed is BRCA2; the disease is familial pancreatic carcinoma.