Both in vitro and in vivo studies have reported that codonolactone inhibited EMT and breast cancer metastasis by downregulating TGF‐β signaling pathway and Runx2 phosphorylation.41 Our experiment results confirmed that FH could prevent tumor metastasis in TNBC xenograft tumor zebrafish and reverse EMT in TGFβ1‐treated MDA‐MB‐231 cells. The gene discussed is RUNX2; the disease is breast cancer.