In this study, we propose to examine the effect of Fangjihuangqi Decoction on triple‐negative breast cancer and EMT in TGFβ1‐treated MDA‐MB‐231 cells and xenograft tumor zebrafish model, which as a chemotherapy drug is clinically more convenient and helpful for TNBC treatment. This evidence concerns the gene TGFB1 and neoplasm.