Regarding the potential target(s) of GATA6 that might be crucial in stimulating CRCSCs, liver receptor homolog‐1 (LRH‐1) is of particular interest because this transcription factor has been reported to play a role in CSC stemness and EMT in pancreatic cancer (Luo et al., 2017). The gene discussed is NR5A2; the disease is pancreatic neoplasm.