Following the first report of the effect of SRR deletion on ischemic brain damage,160 we have evaluated the neuroprotective effect of the elimination of D‐serine in a mouse ischemic stroke model.161 SRR‐KO mice exhibited smaller infarct volumes and better functional recovery, compared with control mice, after experimental middle cerebral artery occlusion and reperfusion, indicating that D‐serine deletion can, at least in stroke, be used as a neuroprotective strategy.161 However, L‐serine deletion does not necessarily enable neuroprotection. This evidence concerns the gene SRR and ischemic stroke.