In fact, the two studies with small sample size did not focus on the clinical value of circulating basophil count, without comparison to the prognostic value of serum CEA which had long been accepted as the most important and reliable prognostic factor in CRC, without detailed descriptions of the prognostic significance of circulating basophil count or comprehensive investigation of the mechanisms behind. This evidence concerns the gene CEACAM5 and colorectal carcinoma.