The encoded protein is required for ciliogenesis, and Ubxn10 depletion caused cardiac laterality defects in zebrafish.31 Predicted loss-of-function variants in GMDS (Ebstein anomaly), SRPK2 (HLHS), and TOP2A (HLHS) were also considered candidates for the cardiac phenotypes (supplementary information). This evidence concerns the gene TOP2A and Ebstein anomaly.