A family with hypertrophic cardiomyopathy had a predicted damaging, cosegregating missense substitution p.(Gly2080Arg) in FLNC, located in a previously disease-associated transmembrane domain.23 A patient with dextrocardia and a complex heart defect, short stature, and failure to thrive was identified with rare, compound heterozygous missense variants p.(Thr331Ala) and (Phe3591Leu) in DNAH8, a gene associated with primary ciliary dyskinesia. This evidence concerns the gene FLNC and primary ciliary dyskinesia.