For two variants, though they were classified as likely pathogenic, the causal link to the presenting cardiac condition remained uncertain: a de novo 9-kb deletion of the first exon and promoter region of DSG2 was identified in a 6-year-old proband with atrial septal defect and dilated right ventricle, but was considered a secondary finding. This evidence concerns the gene DSG2 and Abnormal cardiac septum morphology.