TPCN1 and heart failure: TPCN1 encodes a lysosomal ion channel (i.e., Ca2+), and increased expression was associated with dilated cardiomyopathy and heart failure.30 A homozygous frameshift deletion p.(Ser159Argfs*44) in UBXN10 was found in a patient with congenitally corrected transposition of the great arteries, VSD, and pulmonary stenosis.