ALB and diabetes mellitus: Endothelial glycocalyx has multiple roles in vascular homeostasis,17 and its disruption contributes to several vascular diseases including diabetes.6, 7, 8,18 Our group and others have shown that the glomerular endothelial glycocalyx contributes to the barrier to albumin permeability in cultured cells18, 19, 20 and in vivo.21, 22, 23, 24 Loss of glycosaminoglycan within the glomerular capillary wall is seen in albuminuric diabetic rats25 and diabetic mice.26